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During long-term, open-label therapy, ESL demonstrated statistically significant improvement from baseline in the overall MADRS score. Dosage should be adjusted to the needs of the individual patient. In certain cases, discontinuation of therapy may be necessary. Bacterial and mammalian mutagenicity studies using Carbamazepine produced negative results. We will work closely carbamazepine overnattning with our European partner Eisai to launch Zebinix across the EU during 2009 and into 2010. Oral, and levonorgestrel subdermal implant contraceptives may render the contraceptives less effective because the plasma concentrations of the hormones may be decreased.

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